Anti-HES1 antibody (STJ192322)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Transcription factor HES-1 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HES1 |
| Gene ID | 3280 |
| Uniprot ID | HES1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | HES1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. |
| Protein Name | Transcription Factor Hes-1Class B Basic Helix-Loop-Helix Protein 39Bhlhb39Hairy And Enhancer Of Split 1Hairy HomologHairy-Like ProteinHhl |
| Database Links | Reactome: R-HSA-210744Reactome: R-HSA-2122947Reactome: R-HSA-2197563Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-8940973Reactome: R-HSA-8941856Reactome: R-HSA-9013508Reactome: R-HSA-9013695 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Hes-1 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 39 antibodyAnti-Bhlhb39 antibodyAnti-Hairy And Enhancer Of Split 1 antibodyAnti-Hairy Homolog antibodyAnti-Hairy-Like Protein antibodyAnti-Hhl antibodyAnti-HES1 antibodyAnti-BHLHB39 antibodyAnti-HL antibodyAnti-HRY antibody |
Information sourced from Uniprot.org