| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Rabbit monoclonal antibody anti-Transcription Factor Hes-1 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : |
Monoclonal |
| Clone ID : |
PT0857R |
| Conjugation: |
Unconjugated |
| Isotype: |
IgGk |
| Formulation: |
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification: |
Protein A |
| Dilution Range: |
IHC 1:4000-1:20000WB 1:2000-1:10000IF 1:200-1:1000ELISA 1:5000-1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Function | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. |
| Protein Name | Transcription Factor Hes-1Class B Basic Helix-Loop-Helix Protein 39Bhlhb39Hairy And Enhancer Of Split 1Hairy HomologHairy-Like ProteinHhl |
| Database Links | Reactome: R-HSA-210744Reactome: R-HSA-2122947Reactome: R-HSA-2197563Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-8940973Reactome: R-HSA-8941856Reactome: R-HSA-9013508Reactome: R-HSA-9013695 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Hes-1 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 39 antibodyAnti-Bhlhb39 antibodyAnti-Hairy And Enhancer Of Split 1 antibodyAnti-Hairy Homolog antibodyAnti-Hairy-Like Protein antibodyAnti-Hhl antibodyAnti-HES1 antibodyAnti-BHLHB39 antibodyAnti-HL antibodyAnti-HRY antibody |
Information sourced from Uniprot.org
