| Tissue Specificity | Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia. |
| Function | Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). |
| Protein Name | HemogenErythroid Differentiation-Associated Gene ProteinEdag-1Hemopoietic Gene ProteinNegative Differentiation Regulator Protein |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Hemogen antibodyAnti-Erythroid Differentiation-Associated Gene Protein antibodyAnti-Edag-1 antibodyAnti-Hemopoietic Gene Protein antibodyAnti-Negative Differentiation Regulator Protein antibodyAnti-HEMGN antibodyAnti-EDAG antibodyAnti-NDR antibodyAnti-PRO1037 antibodyAnti-PRO1620 antibody |
Information sourced from Uniprot.org
