| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | HECTD3 |
| Gene ID: | 79654 |
| Uniprot ID: | HECD3_HUMAN |
| Immunogen Region: | 642-861 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 642-861 of human HECTD3 (NP_078878.3). |
| Immunogen Sequence: | DSVLVKLLEVMEGMDKETFE FKFGKELTFTTVLSDQQVVE LIPGGAGIVVGYGDRSRFIQ LVQKARLEESKEQVAAMQAG LLKVVPQAVLDLLTWQELEK KVCGDPEVTVDALRKLTRFE DFEPSDSRVQYFWEALNNFT NEDRSRFLRFVTGRSRLPAR IYIYPDKLGYETTDALPESS TCSSTLFLPHYASAKVCEEK LRYAAYNCVAIDTDMSPWEE |
| Function | E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8. |
| Protein Name | E3 Ubiquitin-Protein Ligase Hectd3Hect Domain-Containing Protein 3Hect-Type E3 Ubiquitin Transferase Hectd3 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hectd3 antibodyAnti-Hect Domain-Containing Protein 3 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Hectd3 antibodyAnti-HECTD3 antibody |
Information sourced from Uniprot.org