| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HDAC11 |
| Gene ID: | 79885 |
| Uniprot ID: | HDA11_HUMAN |
| Immunogen Region: | 270-347 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-347 of human HDAC11 (NP_079103.2). |
| Immunogen Sequence: | GLSISPAGIVKRDELVFRMV RGRRVPILMVTSGGYQKRTA RIIADSILNLFGLGLIGPES PSVSAQNSDTPLLPPAVP |
| Tissue Specificity | Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis. |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
| Protein Name | Histone Deacetylase 11Hd11 |
| Database Links | Reactome: R-HSA-2122947Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-350054 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Histone Deacetylase 11 antibodyAnti-Hd11 antibodyAnti-HDAC11 antibody |
Information sourced from Uniprot.org