| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-HCN3 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000. WB: Approx 85kDa band observed in Rat Kidney lysates (calculated MW of 86.0kDa according to Human NP_065948.1 and 86.8kDa according to Rat NP_446137.1). Recommended concentration: 1-3µg/ml |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | HCN3 |
| Gene ID: | 57657 |
| Uniprot ID: | HCN3_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_065948.1 |
| Immunogen Sequence: | RGVRGRAPSTGAQ |
| Function | Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). In particular, plays a pivotal role in maintaining excitability and promoting rhythmic burst firing within hypothalamic nuclei. Exerts a significant influence on the configuration of the cardiac action potential waveform. Does not appear to play a prominent role in the processing of acute, neuropathic, or inflammatory pain. |
| Protein Name | Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 3 |
| Database Links | Reactome: R-HSA-1296061 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium/Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 3 antibody Anti-HCN3 antibody Anti-KIAA1535 antibody |
Information sourced from Uniprot.org