| Tissue Specificity | Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle. |
| Function | Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate. |
| Protein Name | Mrna-Capping EnzymeHcap1Hce Includes - Mrna 5'-Triphosphate MonophosphataseMrna 5'-Phosphatase - Mrna GuanylyltransferaseGtp--Rna GuanylyltransferaseGtase |
| Database Links | Reactome: R-HSA-167160Reactome: R-HSA-72086Reactome: R-HSA-77075 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mrna-Capping Enzyme antibodyAnti-Hcap1 antibodyAnti-Hce Includes - Mrna 5'-Triphosphate Monophosphatase antibodyAnti-Mrna 5'-Phosphatase - Mrna Guanylyltransferase antibodyAnti-Gtp--Rna Guanylyltransferase antibodyAnti-Gtase antibodyAnti-RNGTT antibodyAnti-CAP1A antibody |
Information sourced from Uniprot.org
