| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-HCAP-H (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 110kDa band observed in lysates of cell line K562 (calculated MW of 82.6kDa according to NP_056156.2). The observed molecular weight corresponds to earlier findings in literatu |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
NCAPH |
| Gene ID: |
23397 |
| Uniprot ID: |
CND2_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_056156.2 |
| Immunogen Sequence: |
TEDLSDVLVRQGD |
| Post Translational Modifications | Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation. |
| Function | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. |
| Protein Name | Condensin Complex Subunit 2Barren Homolog Protein 1Chromosome-Associated Protein HHcap-HNon-Smc Condensin I Complex Subunit HXcap-H Homolog |
| Database Links | Reactome: R-HSA-2514853 |
| Cellular Localisation | NucleusCytoplasmChromosomeIn Interphase CellsThe Majority Of The Condensin Complex Is Found In The CytoplasmWhile A Minority Of The Complex Is Associated With ChromatinA Subpopulation Of The Complex However Remains Associated With Chromosome Foci In Interphase CellsDuring MitosisMost Of The Condensin Complex Is Associated With The ChromatinAt The Onset Of ProphaseThe Regulatory Subunits Of The Complex Are Phosphorylated By Cdk1Leading To Condensin's Association With Chromosome Arms And To Chromosome CondensationDissociation From Chromosomes Is Observed In Late Telophase |
| Alternative Antibody Names | Anti-Condensin Complex Subunit 2 antibodyAnti-Barren Homolog Protein 1 antibodyAnti-Chromosome-Associated Protein H antibodyAnti-Hcap-H antibodyAnti-Non-Smc Condensin I Complex Subunit H antibodyAnti-Xcap-H Homolog antibodyAnti-NCAPH antibodyAnti-BRRN antibodyAnti-BRRN1 antibodyAnti-CAPH antibodyAnti-KIAA0074 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
