| Host: | Rabbit |
| Applications: | WB/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-HBEGF (20-160) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HBEGF |
| Gene ID: | 1839 |
| Uniprot ID: | HBEGF_HUMAN |
| Immunogen Region: | 20-160 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human HB-EGF (NP_001936.1). |
| Immunogen Sequence: | LVTGESLERLRRGLAAGTSN PDPPTVSTDQLLPLGGGRDR KVRDLQEADLDLLRVTLSSK PQALATPNKEEHGKRKKKGK GLGKKRDPCLRKYKDFCIHG ECKYVKELRAPSCICHPGYH GERCHGLSLPVENRLYTYDH T |
| Post Translational Modifications | Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active. O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44. |
| Function | Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. |
| Protein Name | Proheparin-Binding Egf-Like Growth Factor Cleaved Into - Heparin-Binding Egf-Like Growth FactorHb-EgfHbegfDiphtheria Toxin ReceptorDt-R |
| Database Links | Reactome: R-HSA-1227986Reactome: R-HSA-1236394Reactome: R-HSA-1250196Reactome: R-HSA-1250342Reactome: R-HSA-1250347Reactome: R-HSA-1251985Reactome: R-HSA-1257604Reactome: R-HSA-177929Reactome: R-HSA-179812Reactome: R-HSA-180292Reactome: R-HSA-180336Reactome: R-HSA-182971Reactome: R-HSA-1963640Reactome: R-HSA-1963642Reactome: R-HSA-212718Reactome: R-HSA-2179392Reactome: R-HSA-2219530Reactome: R-HSA-5336415Reactome: R-HSA-5638303Reactome: R-HSA-5673001Reactome: R-HSA-6785631Reactome: R-HSA-6811558Reactome: R-HSA-8847993Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8857538Reactome: R-HSA-8863795Reactome: R-HSA-9009391Reactome: R-HSA-9634638Reactome: R-HSA-9664565Reactome: R-HSA-9665686 |
| Cellular Localisation | Heparin-Binding Egf-Like Growth Factor: SecretedExtracellular SpaceMature Hb-Egf Is Released Into The Extracellular Space And Probably Binds To A ReceptorProheparin-Binding Egf-Like Growth Factor: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Proheparin-Binding Egf-Like Growth Factor Cleaved Into - Heparin-Binding Egf-Like Growth Factor antibodyAnti-Hb-Egf antibodyAnti-Hbegf antibodyAnti-Diphtheria Toxin Receptor antibodyAnti-Dt-R antibodyAnti-HBEGF antibodyAnti-DTR antibodyAnti-DTS antibodyAnti-HEGFL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
