Anti-HBB antibody (47-147) (STJ111074)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HBB (47-147) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HBB |
| Gene ID | 3043 |
| Uniprot ID | HBB_HUMAN |
| Immunogen Region | 47-147 |
| Immunogen Sequence | GDLSTPDAVMGNPKVKAHGK KVLGAFSDGLAHLDNLKGTF ATLSELHCDKLHVDPENFRL LGNVLVCVLAHHFGKEFTPP VQAAYQKVVAGVANALAHKY H |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 47-147 of human HBB (NP_000509.1). |
Additional Info
| Tissue Specificity | Red blood cells. |
| Post Translational Modifications | Glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage. This takes place slowly and continuously throughout the 120-day life span of the red blood cell. The rate of glycation is increased in patients with diabetes mellitus. S-nitrosylated.a nitric oxide group is first bound to Fe(2+) and then transferred to Cys-94 to allow capture of O(2). Acetylated on Lys-60, Lys-83 and Lys-145 upon aspirin exposure. |
| Function | Involved in oxygen transport from the lung to the various peripheral tissues. LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Spinorphin: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| Protein Name | Hemoglobin Subunit BetaBeta-GlobinHemoglobin Beta Chain Cleaved Into - Lvv-Hemorphin-7 - Spinorphin |
| Database Links | Reactome: R-HSA-1237044Reactome: R-HSA-1247673Reactome: R-HSA-2168880Reactome: R-HSA-6798695Reactome: R-HSA-9613829Reactome: R-HSA-9615710Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-983231 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Hemoglobin Subunit Beta antibodyAnti-Beta-Globin antibodyAnti-Hemoglobin Beta Chain Cleaved Into - Lvv-Hemorphin-7 - Spinorphin antibodyAnti-HBB antibody |
Information sourced from Uniprot.org