| Tissue Specificity | Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines. |
| Post Translational Modifications | Autophosphorylated on both serine and threonine residues. Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis. |
| Function | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. |
| Protein Name | Serine/Threonine-Protein Kinase HaspinGerm Cell-Specific Gene 2 ProteinH-HaspinHaploid Germ Cell-Specific Nuclear Protein Kinase |
| Cellular Localisation | NucleusChromosomeCytoplasmCytoskeletonSpindleNuclear During Interphase And Associates With The Chromosomes And Spindle Apparatus During Mitosis |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Haspin antibodyAnti-Germ Cell-Specific Gene 2 Protein antibodyAnti-H-Haspin antibodyAnti-Haploid Germ Cell-Specific Nuclear Protein Kinase antibodyAnti-HASPIN antibodyAnti-GSG2 antibody |
Information sourced from Uniprot.org
