| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Serine/threonine-protein kinase haspin (270-350 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HASPIN |
| Gene ID: |
83903 |
| Uniprot ID: |
HASP_HUMAN |
| Immunogen Region: |
270-350 aa |
| Specificity: |
HASP Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 270-350 |
| Post Translational Modifications | Autophosphorylated on both serine and threonine residues. Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis. |
| Function | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. |
| Protein Name | Serine/Threonine-Protein Kinase HaspinGerm Cell-Specific Gene 2 ProteinH-HaspinHaploid Germ Cell-Specific Nuclear Protein Kinase |
| Cellular Localisation | NucleusChromosomeCytoplasmCytoskeletonSpindleNuclear During Interphase And Associates With The Chromosomes And Spindle Apparatus During Mitosis |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Haspin antibodyAnti-Germ Cell-Specific Gene 2 Protein antibodyAnti-H-Haspin antibodyAnti-Haploid Germ Cell-Specific Nuclear Protein Kinase antibodyAnti-HASPIN antibodyAnti-GSG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
