• Immunohistochemistry analysis of paraffin-embedded human brain tissue, using HAND1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

Anti-HAND1 antibody (71-120 aa) (STJ92866)

SKU:
STJ92866

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Heart-and neural crest derivatives-expressed protein 1 (71-120 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HAND1
Gene ID: 9421
Uniprot ID: HAND1_HUMAN
Immunogen Region: 71-120 aa
Specificity: HAND1 Polyclonal Antibody detects endogenous levels of HAND1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human HAND1 at the amino acid range 71-120
Post Translational Modifications Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity.
Function Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes.
Protein Name Heart- And Neural Crest Derivatives-Expressed Protein 1
Class A Basic Helix-Loop-Helix Protein 27
Bhlha27
Extraembryonic Tissues - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 1
Ehand
Database Links Reactome: R-HSA-9733709
Cellular Localisation Nucleus
Nucleoplasm
Nucleolus
Interaction With Mdfic Sequesters It Into The Nucleolus
Preventing The Transcription Factor Activity
Phosphorylation By Plk4 Disrupts The Interaction With Mdfic And Releases It From The Nucleolus
Leading To Transcription Factor Activity
Alternative Antibody Names Anti-Heart- And Neural Crest Derivatives-Expressed Protein 1 antibody
Anti-Class A Basic Helix-Loop-Helix Protein 27 antibody
Anti-Bhlha27 antibody
Anti-Extraembryonic Tissues - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 1 antibody
Anti-Ehand antibody
Anti-HAND1 antibody
Anti-BHLHA27 antibody
Anti-EHAND antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance