| Post Translational Modifications | Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to translocation into the nucleoplasm, allowing dimerization and transcription factor activity. |
| Function | Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes. |
| Protein Name | Heart- And Neural Crest Derivatives-Expressed Protein 1Class A Basic Helix-Loop-Helix Protein 27Bhlha27Extraembryonic Tissues - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 1Ehand |
| Database Links | Reactome: R-HSA-9733709 |
| Cellular Localisation | NucleusNucleoplasmNucleolusInteraction With Mdfic Sequesters It Into The NucleolusPreventing The Transcription Factor ActivityPhosphorylation By Plk4 Disrupts The Interaction With Mdfic And Releases It From The NucleolusLeading To Transcription Factor Activity |
| Alternative Antibody Names | Anti-Heart- And Neural Crest Derivatives-Expressed Protein 1 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 27 antibodyAnti-Bhlha27 antibodyAnti-Extraembryonic Tissues - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 1 antibodyAnti-Ehand antibodyAnti-HAND1 antibodyAnti-BHLHA27 antibodyAnti-EHAND antibody |
Information sourced from Uniprot.org
