| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Granzyme M (207-256 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GZMM |
| Gene ID: | 3004 |
| Uniprot ID: | GRAM_HUMAN |
| Immunogen Region: | 207-256 aa |
| Specificity: | The antibody detects endogenous Granzyme M |
| Immunogen: | Synthetic peptide from the human protein at the amino acid range 207-256 |
| Function | Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. |
| Protein Name | Granzyme MMet-1 Serine ProteaseHu-Met-1Met-AseNatural Killer Cell Granular Protease |
| Database Links | Reactome: R-HSA-173736 |
| Cellular Localisation | SecretedCytoplasmic GranuleGranules Of Large Granular Lymphocytes |
| Alternative Antibody Names | Anti-Granzyme M antibodyAnti-Met-1 Serine Protease antibodyAnti-Hu-Met-1 antibodyAnti-Met-Ase antibodyAnti-Natural Killer Cell Granular Protease antibodyAnti-GZMM antibodyAnti-MET1 antibody |
Information sourced from Uniprot.org