| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Guanylyl cyclase-activating protein 2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GUCA1B |
| Gene ID: | 2979 |
| Uniprot ID: | GUC1B_HUMAN |
| Specificity: | This antibody detects endogenous levels of GCAP2 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human GCAP2 |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure. May be involved in cone photoreceptor response and recovery of response in bright light. |
| Protein Name | Guanylyl Cyclase-Activating Protein 2Gcap 2Guanylate Cyclase Activator 1b |
| Database Links | Reactome: R-HSA-2514859 |
| Cellular Localisation | Cell MembraneLipid-AnchorPhotoreceptor Inner SegmentCell ProjectionCiliumPhotoreceptor Outer SegmentSubcellular Location Is Not Affected By Light Or Dark Conditions |
| Alternative Antibody Names | Anti-Guanylyl Cyclase-Activating Protein 2 antibodyAnti-Gcap 2 antibodyAnti-Guanylate Cyclase Activator 1b antibodyAnti-GUCA1B antibodyAnti-GCAP2 antibody |
Information sourced from Uniprot.org
