Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Guanylyl cyclase-activating protein 1 (63-113 aa) is suitable for use in Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | GUCA1A |
Gene ID: | 118142757 |
Uniprot ID: | GUC1A_HUMAN |
Immunogen Region: | 63-113 aa |
Specificity: | This antibody detects endogenous levels of GUC1A at Human/Mouse |
Immunogen: | Synthesized peptide derived from the human GUC1A at the amino acid range 63-113 |
Function | Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure. May be involved in cone photoreceptor light response and recovery of response in bright light. |
Protein Name | Guanylyl Cyclase-Activating Protein 1Gcap 1Guanylate Cyclase Activator 1a |
Database Links | Reactome: R-HSA-2514859 |
Cellular Localisation | MembraneLipid-AnchorPhotoreceptor Inner SegmentCell ProjectionCiliumPhotoreceptor Outer SegmentPresent At Higher Levels In Cone Than In Rod Outer SegmentsSubcellular Location Is Not Affected By Light Or Dark Conditions |
Alternative Antibody Names | Anti-Guanylyl Cyclase-Activating Protein 1 antibodyAnti-Gcap 1 antibodyAnti-Guanylate Cyclase Activator 1a antibodyAnti-GUCA1A antibodyAnti-C6orf131 antibodyAnti-GCAP antibodyAnti-GCAP1 antibodyAnti-GUCA1 antibody |
Information sourced from Uniprot.org