Anti-GRM6 antibody (480-580 aa) (STJ11106256)

SKU:
STJ11106256
£112.50 - £524.50
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: IF/ICC/ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: GRM6
Gene ID: 2916
Uniprot ID: GRM6_HUMAN
Immunogen Region: 480-580 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 480-580 of human GRM6 (NP_000834.2).
Immunogen Sequence: GSASSGGYQAVGQWAETLRL DVEALQWSGDPHEVPSSLCS LPCGPGERKKMVKGVPCCWH CEACDGYRFQVDEFTCEACP GDMRPTPNHTGCRPTPVVRL S
Tissue Specificity Detected in melanocytes.
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
Protein Name Metabotropic Glutamate Receptor 6
Mglur6
Database Links Reactome: R-HSA-418594
Reactome: R-HSA-420499
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Golgi Apparatus Membrane
Cell Projection
Dendrite
Subject To Trafficking From The Endoplasmic Reticulum To The Golgi Apparatus And Then To The Cell Membrane
Alternative Antibody Names Anti-Metabotropic Glutamate Receptor 6 antibody
Anti-Mglur6 antibody
Anti-GRM6 antibody
Anti-GPRC1F antibody
Anti-MGLUR6 antibody

Information sourced from Uniprot.org

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