| Host: |
Rabbit |
| Applications: |
IF/ICC/ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
GRM6 |
| Gene ID: |
2916 |
| Uniprot ID: |
GRM6_HUMAN |
| Immunogen Region: |
480-580 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 480-580 of human GRM6 (NP_000834.2). |
| Immunogen Sequence: |
GSASSGGYQAVGQWAETLRL DVEALQWSGDPHEVPSSLCS LPCGPGERKKMVKGVPCCWH CEACDGYRFQVDEFTCEACP GDMRPTPNHTGCRPTPVVRL S |
| Tissue Specificity | Detected in melanocytes. |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. |
| Protein Name | Metabotropic Glutamate Receptor 6Mglur6 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-420499 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneGolgi Apparatus MembraneCell ProjectionDendriteSubject To Trafficking From The Endoplasmic Reticulum To The Golgi Apparatus And Then To The Cell Membrane |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 6 antibodyAnti-Mglur6 antibodyAnti-GRM6 antibodyAnti-GPRC1F antibodyAnti-MGLUR6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
