Anti-GRM1 antibody (251-300 aa) (STJ94106)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GRM1 at the amino acid range 251-300
General Information
| Short Description | Rabbit polyclonal anti-Metabotropic glutamate receptor 1 (251-300 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRM1 |
| Gene ID | 2911 |
| Uniprot ID | GRM1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GRM1 at the amino acid range 251-300 |
| Immunogen Region | 251-300 aa |
| Specificity | mGluR1 Polyclonal Antibody detects endogenous levels of mGluR1 protein. |
Additional Info
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. May function in the light response in the retina. Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively. |
| Protein Name | Metabotropic Glutamate Receptor 1Mglur1 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-420499Reactome: R-HSA-6794361Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCell ProjectionDendriteLocated In DendriolesSmall Dendrites That Makes Up A Brush Structure Found As The Terminal Specialization Of A Dendrite Of A Unipolar Brush Cell |
| Alternative Antibody Names | Anti-Metabotropic Glutamate Receptor 1 antibodyAnti-Mglur1 antibodyAnti-GRM1 antibodyAnti-GPRC1A antibodyAnti-MGLUR1 antibody |
Information sourced from Uniprot.org