• Immunofluorescence analysis of HeLa cells, using GRK6 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from Jurkat, COLO205, and HUVEC cells, using GRK6 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of Jurkat cells using GRK 6 Polyclonal Antibody

Anti-GRK6 antibody (10-59 aa) (STJ93436)

SKU:
STJ93436

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-G protein-coupled receptor kinase 6 (10-59 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GRK6
Gene ID: 2870
Uniprot ID: GRK6_HUMAN
Immunogen Region: 10-59 aa
Specificity: GRK 6 Polyclonal Antibody detects endogenous levels of GRK 6 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human GRK6 at the amino acid range 10-59
Post Translational Modifications It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.
Function Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Protein Name G Protein-Coupled Receptor Kinase 6
G Protein-Coupled Receptor Kinase Grk6
Database Links Reactome: R-HSA-418555
Cellular Localisation Membrane
Lipid-Anchor
Alternative Antibody Names Anti-G Protein-Coupled Receptor Kinase 6 antibody
Anti-G Protein-Coupled Receptor Kinase Grk6 antibody
Anti-GRK6 antibody
Anti-GPRK6 antibody

Information sourced from Uniprot.org

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