Host: | Rabbit |
Applications: | WB/IF/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-G protein-coupled receptor kinase 6 (10-59 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | GRK6 |
Gene ID: | 2870 |
Uniprot ID: | GRK6_HUMAN |
Immunogen Region: | 10-59 aa |
Specificity: | GRK 6 Polyclonal Antibody detects endogenous levels of GRK 6 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human GRK6 at the amino acid range 10-59 |
Post Translational Modifications | It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. |
Function | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
Protein Name | G Protein-Coupled Receptor Kinase 6G Protein-Coupled Receptor Kinase Grk6 |
Database Links | Reactome: R-HSA-418555 |
Cellular Localisation | MembraneLipid-Anchor |
Alternative Antibody Names | Anti-G Protein-Coupled Receptor Kinase 6 antibodyAnti-G Protein-Coupled Receptor Kinase Grk6 antibodyAnti-GRK6 antibodyAnti-GPRK6 antibody |
Information sourced from Uniprot.org