| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GRIN2D |
| Gene ID: |
2906 |
| Uniprot ID: |
NMDE4_HUMAN |
| Immunogen Region: |
330-480 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 330-480 of human GRIN2D (NP_000827.2). |
| Immunogen Sequence: |
GAQALLRDYGFLPELGHDCR AQNRTHRGESLHRYFMNITW DNRDYSFNEDGFLVNPSLVV ISLTRDRTWEVVGSWEQQTL RLKYPLWSRYGRFLQPVDDT QHLTVATLEERPFVIVEPAD PISGTCIRDSVPCRSQLNRT HSPPPDAPRPE |
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 2dGlun2dEb11Glutamate Nmda Receptor Subunit Epsilon-4N-Methyl D-Aspartate Receptor Subtype 2dNmdar2dNr2d |
| Database Links | Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-6794361Reactome: R-HSA-8849932Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 2d antibodyAnti-Glun2d antibodyAnti-Eb11 antibodyAnti-Glutamate Nmda Receptor Subunit Epsilon-4 antibodyAnti-N-Methyl D-Aspartate Receptor Subtype 2d antibodyAnti-Nmdar2d antibodyAnti-Nr2d antibodyAnti-GRIN2D antibodyAnti-GluN2D antibodyAnti-NMDAR2D antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
