| Host: |
Rabbit |
| Applications: |
WB/IP |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NMDAR2C (N-Term) is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilized |
| Purification: |
This antibody was antigen affinity purified from pooled serum. |
| Dilution Range: |
WB 1:1000IP 3 µl per 200 µg lysate |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Grin2c |
| Gene ID: |
24411 |
| Uniprot ID: |
NMDE3_RAT |
| Immunogen Region: |
N-Term |
| Immunogen: |
Fusion protein from the N-terminal region of the NR2C subunit. |
| Tissue Specificity | Detected in cerebellum. |
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 2cGlun2cGlutamate Nmda Receptor Subunit Epsilon-3N-Methyl D-Aspartate Receptor Subtype 2cNmdar2cNr2c |
| Database Links | Reactome: R-RNO-438066Reactome: -RNO-8849932Reactome: -RNO-9609736 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 2c antibodyAnti-Glun2c antibodyAnti-Glutamate Nmda Receptor Subunit Epsilon-3 antibodyAnti-N-Methyl D-Aspartate Receptor Subtype 2c antibodyAnti-Nmdar2c antibodyAnti-Nr2c antibodyAnti-Grin2c antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
