• Immunohistochemistry analysis of paraffin-embedded human brain tissue, using NMDAR1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from Jurkat cells, using NMDAR1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of NIH/3T3 cells, using NMDAR1 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-GRIN1 antibody (856-905) (STJ94523)

SKU:
STJ94523

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Glutamate receptor ionotropic, NMDA 1 (856-905) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GRIN1
Gene ID: 2902
Uniprot ID: NMDZ1_HUMAN
Immunogen Region: 856-905
Specificity: NMDA Zeta 1 Polyclonal Antibody detects endogenous levels of NMDA Zeta 1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human NMDAR1. AA range:856-905
Post Translational Modifications NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.
Function Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.
Protein Name Glutamate Receptor Ionotropic - Nmda 1
Glun1
Glutamate Nmda Receptor Subunit Zeta-1
N-Methyl-D-Aspartate Receptor Subunit Nr1
Nmd-R1
Database Links Reactome: R-HSA-3928662
Reactome: R-HSA-438066
Reactome: R-HSA-442982
Reactome: R-HSA-5673001
Reactome: R-HSA-6794361
Reactome: R-HSA-8849932
Reactome: R-HSA-9609736
Reactome: R-HSA-9617324
Reactome: R-HSA-9620244
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Postsynaptic Density
Enriched In Postsynaptic Plasma Membrane And Postsynaptic Densities
Alternative Antibody Names Anti-Glutamate Receptor Ionotropic - Nmda 1 antibody
Anti-Glun1 antibody
Anti-Glutamate Nmda Receptor Subunit Zeta-1 antibody
Anti-N-Methyl-D-Aspartate Receptor Subunit Nr1 antibody
Anti-Nmd-R1 antibody
Anti-GRIN1 antibody
Anti-NMDAR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance