| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
GRIK3 |
| Gene ID: |
2899 |
| Uniprot ID: |
GRIK3_HUMAN |
| Immunogen Region: |
32-240 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 32-240 of human GRIK3 (NP_000822.2). |
| Immunogen Sequence: |
MPHVIRIGGIFEYADGPNAQ VMNAEEHAFRFSANIINRNR TLLPNTTLTYDIQRIHFHDS FEATKKACDQLALGVVAIFG PSQGSCTNAVQSICNALEVP HIQLRWKHHPLDNKDTFYVN LYPDYASLSHAILDLVQYLK WRSATVVYDDSTGLIRLQEL IMAPSRYNIRLKIRQLPIDS DDSRPLLKEMKRGREFRIIF DCSHTMAAQ |
| Function | Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In association with GRIK2, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses. |
| Protein Name | Glutamate Receptor Ionotropic - Kainate 3Gluk3Excitatory Amino Acid Receptor 5Eaa5Glutamate Receptor 7Glur-7Glur7 |
| Database Links | Reactome: R-HSA-451308Reactome: R-HSA-500657 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Kainate 3 antibodyAnti-Gluk3 antibodyAnti-Excitatory Amino Acid Receptor 5 antibodyAnti-Eaa5 antibodyAnti-Glutamate Receptor 7 antibodyAnti-Glur-7 antibodyAnti-Glur7 antibodyAnti-GRIK3 antibodyAnti-GLUR7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
