| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Rat/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-GRIA4, Biotinylated (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx. 90kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 99.2kDa according to NP_001070711.1). Recommended concentration: 0.3-1µg/ml. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
GRIA4 |
| Gene ID: |
2893 |
| Uniprot ID: |
GRIA4_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_000820.3; NP_001070711.1; NP_001070712.1 |
| Immunogen Sequence: |
CKKLDQREYPGSETP. |
| Function | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. |
| Protein Name | Glutamate Receptor 4Glur-4Glur4Ampa-Selective Glutamate Receptor 4Glur-DGlutamate Receptor Ionotropic - Ampa 4 |
| Database Links | Reactome: R-HSA-399710Reactome: R-HSA-399719Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-8849932 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Glutamate Receptor 4 antibodyAnti-Glur-4 antibodyAnti-Glur4 antibodyAnti-Ampa-Selective Glutamate Receptor 4 antibodyAnti-Glur-D antibodyAnti-Glutamate Receptor Ionotropic - Ampa 4 antibodyAnti-GRIA4 antibodyAnti-GluA4 antibodyAnti-GLUR4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
