• Western blot analysis of lysates from HUVEC, COLO, and MCF-7 cells, using GRB14 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using GRB14 Polyclonal Antibody

Anti-GRB14 antibody (81-130 aa) (STJ93420)

SKU:
STJ93420

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Growth factor receptor-bound protein 14 (81-130 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GRB14
Gene ID: 2888
Uniprot ID: GRB14_HUMAN
Immunogen Region: 81-130 aa
Specificity: GRB14 Polyclonal Antibody detects endogenous levels of GRB14 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human GRB14 at the amino acid range 81-130
Post Translational Modifications Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2.
Function Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Protein Name Growth Factor Receptor-Bound Protein 14
Grb14 Adapter Protein
Database Links Reactome: R-HSA-210993
Cellular Localisation Cytoplasm
Endosome Membrane
Peripheral Membrane Protein
Upon Insulin Stimulation
Translocates To The Plasma Membrane
Alternative Antibody Names Anti-Growth Factor Receptor-Bound Protein 14 antibody
Anti-Grb14 Adapter Protein antibody
Anti-GRB14 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance