| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Growth factor receptor-bound protein 14 (81-130 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GRB14 |
| Gene ID: | 2888 |
| Uniprot ID: | GRB14_HUMAN |
| Immunogen Region: | 81-130 aa |
| Specificity: | GRB14 Polyclonal Antibody detects endogenous levels of GRB14 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human GRB14 at the amino acid range 81-130 |
| Post Translational Modifications | Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2. |
| Function | Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. |
| Protein Name | Growth Factor Receptor-Bound Protein 14Grb14 Adapter Protein |
| Database Links | Reactome: R-HSA-210993 |
| Cellular Localisation | CytoplasmEndosome MembranePeripheral Membrane ProteinUpon Insulin StimulationTranslocates To The Plasma Membrane |
| Alternative Antibody Names | Anti-Growth Factor Receptor-Bound Protein 14 antibodyAnti-Grb14 Adapter Protein antibodyAnti-GRB14 antibody |
Information sourced from Uniprot.org