| Host: |
Mouse |
| Applications: |
IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Granzyme B is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
11F1 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2a |
| Formulation: |
Tissue culture supernatant with Sodium azide |
| Concentration: |
>=47 mg/L |
| Dilution Range: |
IHC-P 1:80 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
GZMB |
| Gene ID: |
3002 |
| Uniprot ID: |
GRAB_HUMAN |
| Immunogen: |
Recombinant prokaryotic fusion protein corresponding to the N-terminus of the mature granzyme B molecule. |
| Function | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. |
| Protein Name | Granzyme BC11Ctla-1Cathepsin G-Like 1Ctsgl1Cytotoxic T-Lymphocyte Proteinase 2Lymphocyte ProteaseFragmentin-2Granzyme-2Human Lymphocyte ProteinHlpSectT-Cell Serine Protease 1-3e |
| Database Links | Reactome: R-HSA-2197563Reactome: R-HSA-5620971Reactome: R-HSA-75108 |
| Cellular Localisation | SecretedCytolytic GranuleDelivered Into The Target Cell By Perforin |
| Alternative Antibody Names | Anti-Granzyme B antibodyAnti-C11 antibodyAnti-Ctla-1 antibodyAnti-Cathepsin G-Like 1 antibodyAnti-Ctsgl1 antibodyAnti-Cytotoxic T-Lymphocyte Proteinase 2 antibodyAnti-Lymphocyte Protease antibodyAnti-Fragmentin-2 antibodyAnti-Granzyme-2 antibodyAnti-Human Lymphocyte Protein antibodyAnti-Hlp antibodyAnti-Sect antibodyAnti-T-Cell Serine Protease 1-3e antibodyAnti-GZMB antibodyAnti-CGL1 antibodyAnti-CSPB antibodyAnti-CTLA1 antibodyAnti-GRB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
