| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospholipid hydroperoxide glutathione peroxidase (84-134 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPX4 |
| Gene ID: |
2879 |
| Uniprot ID: |
GPX4_HUMAN |
| Immunogen Region: |
84-134 aa |
| Specificity: |
This antibody detects endogenous levels of GPX4 at Human |
| Immunogen: |
Synthesized peptide derived from the human GPX4 at the amino acid range 84-134 |
| Function | Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis. The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures. May be required to protect cells from the toxicity of ingested lipid hydroperoxides. Required for normal sperm development and male fertility. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion. Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism. Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway. |
| Protein Name | Phospholipid Hydroperoxide Glutathione PeroxidasePhgpxGlutathione Peroxidase 4Gpx-4Gshpx-4 |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142712Reactome: R-HSA-2142770Reactome: R-HSA-9018676 P36969-2Reactome: R-HSA-9018896 P36969-2Reactome: R-HSA-9020265 P36969-2Reactome: R-HSA-9023661 P36969-2 |
| Cellular Localisation | Isoform Mitochondrial: MitochondrionIsoform Cytoplasmic: Cytoplasm |
| Alternative Antibody Names | Anti-Phospholipid Hydroperoxide Glutathione Peroxidase antibodyAnti-Phgpx antibodyAnti-Glutathione Peroxidase 4 antibodyAnti-Gpx-4 antibodyAnti-Gshpx-4 antibodyAnti-GPX4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
