| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPS1 |
| Gene ID: | 2873 |
| Uniprot ID: | CSN1_HUMAN |
| Immunogen Region: | 258-527 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 258-527 of human GPS1 (NP_997657.1). |
| Immunogen Sequence: | VSKAESTPEIAEQRGERDSQ TQAILTKLKCAAGLAELAAR KYKQAAKCLLLASFDHCDFP ELLSPSNVAIYGGLCALATF DRQELQRNVISSSSFKLFLE LEPQVRDIIFKFYESKYASC LKMLDEMKDNLLLDMYLAPH VRTLYTQIRNRALIQYFSPY VSADMHRMAAAFNTTVAALE DELTQLILEGLISARVDSHS KILYARDVDQRSTTFEKSLL MGKEFQRRAKAMMLRAAVL |
| Tissue Specificity | Widely expressed. |
| Function | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. |
| Protein Name | Cop9 Signalosome Complex Subunit 1 Sgn1 Signalosome Subunit 1 G Protein Pathway Suppressor 1 Gps-1 Jab1-Containing Signalosome Subunit 1 Protein Mfh |
| Database Links | Reactome: R-HSA-5696394 Reactome: R-HSA-6781823 Reactome: R-HSA-8856825 Reactome: R-HSA-8951664 Reactome: R-HSA-9013422 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Cop9 Signalosome Complex Subunit 1 antibody Anti-Sgn1 antibody Anti-Signalosome Subunit 1 antibody Anti-G Protein Pathway Suppressor 1 antibody Anti-Gps-1 antibody Anti-Jab1-Containing Signalosome Subunit 1 antibody Anti-Protein Mfh antibody Anti-GPS1 antibody Anti-COPS1 antibody Anti-CSN1 antibody |
Information sourced from Uniprot.org