| Post Translational Modifications | Phosphorylated by a subset of GPR84-activating ligands. Constitutively phosphorylated at Ser-221 and Ser-224 in the absence of 2-HTP. By contrast, Thr-263 and Thr-264 are phosphorylated only following prior cell treatment with 2-HTP. |
| Function | G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B. In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation. Plays also an important role in inflammation by modulating neutrophil functions. Mechanistically, promotes neutrophil chemotaxis, reactive oxygen species (ROS) production and degranulation via LYN-AKT/ERK pathway. To regulate ROS, communicates with the two formyl peptide receptors FPR2 and FPR1 to control the NADPH oxidase activity in neutrophils. |
| Protein Name | G-Protein Coupled Receptor 84Inflammation-Related G-Protein Coupled Receptor Ex33 |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 84 antibodyAnti-Inflammation-Related G-Protein Coupled Receptor Ex33 antibodyAnti-GPR84 antibodyAnti-EX33 antibody |
Information sourced from Uniprot.org
