Host: |
Rabbit |
Applications: |
WB/ELISA |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-Prosaposin receptor GPR37 (211-260 aa) is suitable for use in Western Blot and ELISA research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
GPR37 |
Gene ID: |
2861 |
Uniprot ID: |
GPR37_HUMAN |
Immunogen Region: |
211-260 aa |
Specificity: |
GPR37 Polyclonal Antibody detects endogenous levels of GPR37 protein. |
Immunogen: |
The antiserum was produced against synthesized peptide derived from the human GPR37 at the amino acid range 211-260 |
Post Translational Modifications | Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death. |
Function | Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. |
Protein Name | Prosaposin Receptor Gpr37Endothelin B Receptor-Like Protein 1Etbr-Lp-1G-Protein Coupled Receptor 37Parkin-Associated Endothelin Receptor-Like ReceptorPaelr |
Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
Alternative Antibody Names | Anti-Prosaposin Receptor Gpr37 antibodyAnti-Endothelin B Receptor-Like Protein 1 antibodyAnti-Etbr-Lp-1 antibodyAnti-G-Protein Coupled Receptor 37 antibodyAnti-Parkin-Associated Endothelin Receptor-Like Receptor antibodyAnti-Paelr antibodyAnti-GPR37 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance