| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADGRG6 |
| Gene ID: |
57211 |
| Uniprot ID: |
AGRG6_HUMAN |
| Immunogen Region: |
40-300 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human GPR126 (NP_001027567.1). |
| Immunogen Sequence: |
NCRVVLSNPSGTFTSPCYPN DYPNSQACMWTLRAPTGYII QITFNDFDIEEAPNCIYDSL SLDNGESQTKFCGATAKGLS FNSSANEMHVSFSSDFSIQK KGFNASYIRVAVSLRNQKVI LPQTSDAYQVSVAKSISIPE LSAFTLCFEATKVGHEDSDW TAFSYSNASFTQLLSFGKAK SGYFLSISDSKCLLNNALPV KEKEDIFAESFEQLCLVWNN SLGSIGVNFKRNYETVPCD |
| Tissue Specificity | Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells. |
| Post Translational Modifications | Highly glycosylated. Proteolytically cleaved into 2 conserved sites: one in the GPS region of the GAIN-B domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS region occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor. |
| Function | G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis. |
| Protein Name | Adhesion G-Protein Coupled Receptor G6Developmentally Regulated G-Protein-Coupled ReceptorG-Protein Coupled Receptor 126Vascular Inducible G Protein-Coupled Receptor Cleaved Into - Adgrg6 N-Terminal FragmentAdgrg6-Ntf - Adgrg6 C-Terminal FragmentAdgrg6-Ctf |
| Database Links | Reactome: R-HSA-9619665 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinDetected On The Cell Surface Of Activated But Not Resting Umbilical Vein |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor G6 antibodyAnti-Developmentally Regulated G-Protein-Coupled Receptor antibodyAnti-G-Protein Coupled Receptor 126 antibodyAnti-Vascular Inducible G Protein-Coupled Receptor Cleaved Into - Adgrg6 N-Terminal Fragment antibodyAnti-Adgrg6-Ntf - Adgrg6 C-Terminal Fragment antibodyAnti-Adgrg6-Ctf antibodyAnti-ADGRG6 antibodyAnti-DREG antibodyAnti-GPR126 antibodyAnti-VIGR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
