| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NTRK3 (40-300) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NTRK3 |
| Gene ID: |
4916 |
| Uniprot ID: |
NTRK3_HUMAN |
| Immunogen Region: |
40-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TrKC (NP_001007157.1). |
| Immunogen Sequence: |
KTEINCRRPDDGNLFPLLEG QDSGNSNGNASINITDISRN ITSIHIENWRSLHTLNAVDM ELYTGLQKLTIKNSGLRSIQ PRAFAKNPHLRYINLSSNRL TTLSWQLFQTLSLRELQLEQ NFFNCSCDIRWMQLWQEQGE AKLNSQNLYCINADGSQLPL FRMNISQCDLPEISVSHVNL TVREGDNAVITCNGSGSPLP DVDWIVTGLQSINTHQTNLN WTNVHAINLTLVNVTSEDN |
| Tissue Specificity | Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain. |
| Post Translational Modifications | Ligand-mediated auto-phosphorylation. |
| Function | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. |
| Protein Name | Nt-3 Growth Factor ReceptorGp145-TrkcTrk-CNeurotrophic Tyrosine Kinase Receptor Type 3Trkc Tyrosine Kinase |
| Database Links | Reactome: R-HSA-388844Reactome: R-HSA-9034013Reactome: R-HSA-9034015Reactome: R-HSA-9034793Reactome: R-HSA-9034864Reactome: R-HSA-9603381Reactome: R-HSA-9603505 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Nt-3 Growth Factor Receptor antibodyAnti-Gp145-Trkc antibodyAnti-Trk-C antibodyAnti-Neurotrophic Tyrosine Kinase Receptor Type 3 antibodyAnti-Trkc Tyrosine Kinase antibodyAnti-NTRK3 antibodyAnti-TRKC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
