| Short Description : | Rabbit polyclonal GPNMB (23-572) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPNMB |
| Gene ID: | 10457 |
| Uniprot ID: | GPNMB_HUMAN |
| Immunogen Region: | 23-572 |
| Immunogen Sequence: | KRFHDVLGNERPSAYMREHN QLNGWSSDENDWNEKLYPVW KRGDMRWKNSWKGGRVQAVL TSDSPALVGSNITFAVNLIF PRCQKEDANGNIVYEKNCRN EAGLSADPYVYNWTAWSEDS DGENGTGQSHHNVFPDGKPF PHHPGWRRWNFIYVFHTLGQ YFQKLGRCSVRVSVNTANVT LGPQLMEVTVYRRHGRAYVP IAQVKDVYVVTDQIPVFVTM FQKNDRNSSDETFLKDLPI |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-486 of human GPNMB (NP_001005340.1). |
| Tissue Specificity | Widely expressed, but very low expression, if any, in the brain. Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level). Expressed in peripheral blood, but not bone marrow mononuclear cells. Expressed in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). May be overexpressed in various cancers, including melanoma and glioblastoma multiforme. |
| Function | Could be a melanogenic enzyme. |
| Protein Name | Transmembrane Glycoprotein NmbHematopoietic Growth Factor Inducible Neurokinin-1 Type |
| Database Links | Reactome: R-HSA-8857538 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMelanosome MembraneEarly Endosome MembraneIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Transmembrane Glycoprotein Nmb antibodyAnti-Hematopoietic Growth Factor Inducible Neurokinin-1 Type antibodyAnti-GPNMB antibodyAnti-HGFIN antibodyAnti-NMB antibodyAnti-UNQ1725 antibodyAnti-PRO9925 antibody |
Information sourced from Uniprot.org
