| Function | Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors. Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
| Protein Name | Gephyrin Includes - Molybdopterin AdenylyltransferaseMpt AdenylyltransferaseDomain G - Molybdopterin MolybdenumtransferaseMpt Mo-TransferaseDomain E |
| Database Links | Reactome: R-HSA-947581 |
| Cellular Localisation | Postsynaptic Cell MembraneLipid-AnchorCytoplasmic SideCell MembraneCytoplasmCytosolCytoskeletonCell ProjectionDendritePostsynaptic DensityCytoplasmic Face Of Glycinergic Postsynaptic MembranesForms Clusters At Synapses |
| Alternative Nanobody Names | Anti-Gephyrin Includes - Molybdopterin Adenylyltransferase nanobodyAnti-Mpt Adenylyltransferase nanobodyAnti-Domain G - Molybdopterin Molybdenumtransferase nanobodyAnti-Mpt Mo-Transferase nanobodyAnti-Domain E nanobodyAnti-GPHN nanobodyAnti-GPH nanobodyAnti-KIAA1385 nanobody |
Information sourced from Uniprot.org
![Anti-GPHN/Gephyrin nanobody [SAA1333] (STJN000330)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200943/413125/STJN000330-SDS-PAGE-1__34292.1749232621.jpg?c=1 "Anti-GPHN/Gephyrin nanobody [SAA1333] (STJN000330)")
![Anti-GPHN/Gephyrin nanobody [SAA1333] (STJN000330)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200943/413125/STJN000330-SDS-PAGE-1__34292.1749232621.jpg?c=1 "Anti-GPHN/Gephyrin nanobody [SAA1333] (STJN000330)")
