Anti-GPC1 antibody [SAA0530] (STJA0027665)

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STJA0027665
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Host: Human
Applications: ELISA/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Human monoclonal antibody anti-Glypican-1 Cleaved Into-Secreted Glypican-1 is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA0530
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1 mg/ml
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: GPC1
Gene ID: 2817
Uniprot ID: GPC1_HUMAN
Function Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.
Protein Name Glypican-1 Cleaved Into - Secreted Glypican-1
Database Links Reactome: R-HSA-1971475
Reactome: R-HSA-2022928
Reactome: R-HSA-2024096
Reactome: R-HSA-202733
Reactome: R-HSA-3560783
Reactome: R-HSA-3560801
Reactome: R-HSA-3656237
Reactome: R-HSA-3656253
Reactome: R-HSA-376176
Reactome: R-HSA-4420332
Reactome: R-HSA-9694614
Reactome: R-HSA-975634
Reactome: R-HSA-9820960
Reactome: R-HSA-9833110
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Extracellular Side
Endosome
S-Nitrosylated Form Recycled In Endosomes
Localizes To Cav1-Containing Vesicles Close To The Cell Surface
Cleavage Of Heparan Sulfate Side Chains Takes Place Mainly In Late Endosomes
Associates With Both Forms Of Prnp In Lipid Rafts
Colocalizes With App In Perinuclear Compartments And With Cp In Intracellular Compartments
Associates With Fibrillar App Amyloid-Beta Peptides In Lipid Rafts In Alzheimer Disease Brains
Secreted Glypican-1: Secreted
Extracellular Space
Alternative Antibody Names Anti-Glypican-1 Cleaved Into - Secreted Glypican-1 antibody
Anti-GPC1 antibody

Information sourced from Uniprot.org