Anti-GOLPH3 antibody (1-298) (STJ115087)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GOLPH3 (1-298) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GOLPH3 |
| Gene ID | 64083 |
| Uniprot ID | GOLP3_HUMAN |
| Immunogen Region | 1-298 |
| Immunogen Sequence | MTSLTQRSSGLVQRRTEASR NAADKERAAGGGAGSSEDDA QSRRDEQDDDDKGDSKETRL TLMEEVLLLGLKDREGYTSF WNDCISSGLRGCMLIELALR GRLQLEACGMRRKSLLTRKV ICKSDAPTGDVLLDEALKHV KETQPPETVQNWIELLSGET WNPLKLHYQLRNVRERLAKN LVEKGVLTTEKQNFLLFDMT THPLTNNNIKQRLIKKVQEA VLDKWVNDPHRMDRRLLAL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human GOLPH3 (NP_071413.1). |
Additional Info
| Tissue Specificity | Detected in muscle fibers of patients with mitochondrial diseases.not detected in normal muscle fibers. |
| Post Translational Modifications | Phosphorylated. |
| Function | Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. |
| Protein Name | Golgi Phosphoprotein 3Coat Protein Gpp34Mitochondrial Dna Absence FactorMidas |
| Database Links | |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembranePeripheral Membrane ProteinCytoplasmic SideTrans-Golgi Network MembraneMitochondrion Intermembrane SpaceCell MembraneEndosomePhosphatidylinositol 4-Phosphate-Binding And Oligomerization Participate In The Recruitment Onto Golgi Membranes |
| Alternative Antibody Names | Anti-Golgi Phosphoprotein 3 antibodyAnti-Coat Protein Gpp34 antibodyAnti-Mitochondrial Dna Absence Factor antibodyAnti-Midas antibodyAnti-GOLPH3 antibodyAnti-GPP34 antibody |
Information sourced from Uniprot.org