Anti-GNAT1 antibody (71-120 aa) (STJ93459)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GNAT1 at the amino acid range 71-120
General Information
| Short Description | Rabbit polyclonal anti-Guanine nucleotide-binding protein Gt subunit alpha-1 (71-120 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GNAT1 |
| Gene ID | 2779 |
| Uniprot ID | GNAT1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GNAT1 at the amino acid range 71-120 |
| Immunogen Region | 71-120 aa |
| Specificity | G Alpha t1 Polyclonal Antibody detects endogenous levels of G Alpha t1 protein. |
Additional Info
| Function | Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina. Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase. |
| Protein Name | Guanine Nucleotide-Binding Protein G(T Subunit Alpha-1Transducin Alpha-1 Chain |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859Reactome: R-HSA-418594 |
| Cellular Localisation | Cell ProjectionCiliumPhotoreceptor Outer SegmentMembranePeripheral Membrane ProteinPhotoreceptor Inner SegmentLocalizes Mainly In The Outer Segment In The Dark-Adapted StateWhereas Is Translocated To The Inner Part Of The Photoreceptors In The Light-Adapted StateDuring Dark-Adapted ConditionsIn The Presence Of Unc119 Mislocalizes From The Outer Segment To The Inner Part Of Rod Photoreceptors Which Leads To Decreased Photoreceptor Damage Caused By Light |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein G(T Subunit Alpha-1 antibodyAnti-Transducin Alpha-1 Chain antibodyAnti-GNAT1 antibodyAnti-GNATR antibody |
Information sourced from Uniprot.org