• STJ72505 (0. 1µg/ml) staining of Mouse (A) and Rat (B) Testis lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • STJ72505 (0. 1µg/ml) staining of Peripheral Blood Lymphocytes lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • STJ72505 (0. 1µg/ml) staining of Pig Colon (A) and Pig Spleen (B) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-GNAQ/ALPHA-q antibody (162-175) (STJ72505)

SKU:
STJ72505-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-GNAQ/ALPHA-q (162-175) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-5µg/ml
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: GNAQ
Gene ID: 2776
Uniprot ID: GNAQ_HUMAN
Immunogen Region: 162-175
Accession Number: NP_002063.2
Immunogen Sequence: NDLDRVADPAYLPT
Post Translational Modifications Palmitoylated by ZDHHC3 and ZDHHC7. Palmitoylation occurs in the Golgi and participates in the localization of GNAQ to the plasma membrane. (Microbial infection) Deamidated at Gln-209 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA. Histaminylated at Gln-209 residues by TGM2.
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Together with GNA11, required for heart development.
Protein Name Guanine Nucleotide-Binding Protein G(Q Subunit Alpha
Guanine Nucleotide-Binding Protein Alpha-Q
Database Links Reactome: R-HSA-112043
Reactome: R-HSA-202040
Reactome: R-HSA-399997
Reactome: R-HSA-416476
Reactome: R-HSA-418592
Reactome: R-HSA-428930
Reactome: R-HSA-434316
Reactome: R-HSA-456926
Reactome: R-HSA-6814122
Cellular Localisation Cell Membrane
Lipid-Anchor
Golgi Apparatus
Nucleus
Nucleus Membrane
Colocalizes With The Adrenergic Receptors
Adren1a And Adren1b
At The Nuclear Membrane Of Cardiac Myocytes
Alternative Antibody Names Anti-Guanine Nucleotide-Binding Protein G(Q Subunit Alpha antibody
Anti-Guanine Nucleotide-Binding Protein Alpha-Q antibody
Anti-GNAQ antibody
Anti-GAQ antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance