Anti-Glycophorin A antibody [R07-2E-1] (STJA0033086)

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STJA0033086
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Host: Mouse
Applications: IHC-P/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-Glycophorin A for use in IHC-P and FC in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : R07-2E-1
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Liquid in PBS, Glycerol and BSA
Purification: Protein G
Dilution Range: IHC-P 1:50-1:100
FC 1:50-1:100
Storage Instruction: Store at-20°C. Avoid freeze/thaw cycles.
Gene Symbol: GYPA
Gene ID: 2993
Uniprot ID: GLPA_HUMAN
Immunogen: Peptide
Post Translational Modifications The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-NeuAc-alpha-(2-6)-GalNAcOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-NeuAc-alpha-(2-6)-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-Fuc-alpha-(1-2)-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-Fuc-alpha-(1-2)-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).
Function Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. (Microbial infection) Appears to be a receptor for Hepatitis A virus (HAV). (Microbial infection) Receptor for P.falciparum erythrocyte-binding antigen 175 (EBA-175).binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans.
Protein Name Glycophorin-A
Mn Sialoglycoprotein
Pas-2
Sialoglycoprotein Alpha
Cd Antigen Cd235a
Database Links Reactome: R-HSA-202733
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Appears To Be Colocalized With Slc4a1
Alternative Antibody Names Anti-Glycophorin-A antibody
Anti-Mn Sialoglycoprotein antibody
Anti-Pas-2 antibody
Anti-Sialoglycoprotein Alpha antibody
Anti-Cd Antigen Cd235a antibody
Anti-GYPA antibody
Anti-GPA antibody
Anti-MNS antibody

Information sourced from Uniprot.org

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