Anti-Glycerol kinase antibody (450-559) [S4MR] (STJ11102954)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Glycerol kinase (GK) (450-559) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GK |
| Gene ID | 2710 |
| Uniprot ID | GLPK_HUMAN |
| Immunogen Region | 450-559 |
| Immunogen Sequence | IPVVKPSMPETTALGAAMAA GAAEGVGVWSLEPEDLSAVT MERFEPQINAEESEIRYSTW KKAVMKSMGWVTTQSPESGD PSIFCSLPLGFFIVSSMVML IGARYISGIP |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 450-559 of human Glycerol kinase (GK) (P32189). |
Additional Info
| Tissue Specificity | Isoform 2: Widely expressed in fetal and adult tissues. Isoform 3: Widely expressed in fetal and adult tissues. Isoform 4: The sole isoform expressed in adult liver and kidney. |
| Function | Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn-glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis. |
| Protein Name | Glycerol KinaseGlycerokinaseAtp -Glycerol 3-Phosphotransferase |
| Database Links | Reactome: R-HSA-75109 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane ProteinNucleusCytoplasmCytosolGlycerol Kinase Activity Is More Cytosolic In Some TissuesIt Probably Represents The Expression Of Isoforms Lacking A Transmembrane DomainIsoform 3: Mitochondrion Outer MembraneIn Sperm And Fetal TissuesThe Majority Of The Activity Is Associated With MitochondriaIsoform 4: CytoplasmIn Adult TissuesSuch As Liver The Glycerol Kinase Activity Is More CytosolicIt Probably Represents The Expression Of This Isoform Which Lacks A Transmembrane Domain |
| Alternative Antibody Names | Anti-Glycerol Kinase antibodyAnti-Glycerokinase antibodyAnti-Atp -Glycerol 3-Phosphotransferase antibodyAnti-GK antibody |
Information sourced from Uniprot.org