| Post Translational Modifications | Synthesized as a 74-kDa cytosolic precursor which is proteolytically processed by the mitochondrial-processing peptidase (MPP) via a 72-kDa intermediate to yield the mature mitochondrial 68- and 65-kDa subunits. |
| Function | Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain. Isoform 2: Lacks catalytic activity. |
| Protein Name | Glutaminase Kidney Isoform - MitochondrialGlsK-GlutaminaseL-Glutamine Amidohydrolase Cleaved Into - Glutaminase Kidney Isoform - Mitochondrial 68 Kda Chain - Glutaminase Kidney Isoform - Mitochondrial 65 Kda Chain |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-5628897Reactome: R-HSA-8964539 |
| Cellular Localisation | Isoform 1: MitochondrionCytoplasmCytosolThe 74-Kda Cytosolic Precursor Is Translocated Into The Mitochondria And Processed Via A 72-Kda Intermediate To Yield The Mature 68- And 65-Kda SubunitsIsoform 3: MitochondrionGlutaminase Kidney IsoformMitochondrial 68 Kda Chain: Mitochondrion MatrixProduced By The Proteolytic Processing Of The 74-Kda Cytosolic PrecursorMitochondrial 65 Kda Chain: Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Glutaminase Kidney Isoform - Mitochondrial antibodyAnti-Gls antibodyAnti-K-Glutaminase antibodyAnti-L-Glutamine Amidohydrolase Cleaved Into - Glutaminase Kidney Isoform - Mitochondrial 68 Kda Chain - Glutaminase Kidney Isoform - Mitochondrial 65 Kda Chain antibodyAnti-GLS antibodyAnti-GLS1 antibodyAnti-KIAA0838 antibody |
Information sourced from Uniprot.org
