| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-GLP-1-R-Mouse (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 55kDa band observed in Mouse Heart lysates (calculated MW of 53.0kDa according to NP_067307.2). Recommended concentration: 1-3µg/ml. Primary incubation was 1 hour.IHC: Par |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: | Internal |
| Accession Number: | NP_067307.2 |
| Specificity: | The immunizing peptide represents part of an extracellular region. |
| Immunogen Sequence: | SKRGERNFPEEQ |
| Post Translational Modifications | N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER. |
| Function | G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. |
| Protein Name | Glucagon-Like Peptide 1 ReceptorGlp-1 ReceptorGlp-1-RGlp-1r |
| Database Links | Reactome: R-MMU-381676Reactome: -MMU-418555Reactome: -MMU-420092 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Glucagon-Like Peptide 1 Receptor antibodyAnti-Glp-1 Receptor antibodyAnti-Glp-1-R antibodyAnti-Glp-1r antibodyAnti-Glp1r antibody |
Information sourced from Uniprot.org
