Anti-GLO1 antibody (1-100) [S2MR] (STJ11102042)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal GLO1 (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GLO1 |
| Gene ID | 2739 |
| Uniprot ID | LGUL_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MAEPQPPSGGLTDEAALSCC SDADPSTKDFLLQQTMLRVK DPKKSLDFYTRVLGMTLIQK CDFPIMKFSLYFLAYEDKND IPKEKDEKIAWALSRKATLE |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GLO1 (Q04760). |
Additional Info
| Post Translational Modifications | Glutathionylation at Cys-139 inhibits enzyme activity. Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B. Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B. |
| Function | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. |
| Protein Name | Lactoylglutathione LyaseAldoketomutaseGlyoxalase IGlx IKetone-Aldehyde MutaseMethylglyoxalaseS-D-Lactoylglutathione Methylglyoxal Lyase |
| Database Links | Reactome: R-HSA-70268 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Lactoylglutathione Lyase antibodyAnti-Aldoketomutase antibodyAnti-Glyoxalase I antibodyAnti-Glx I antibodyAnti-Ketone-Aldehyde Mutase antibodyAnti-Methylglyoxalase antibodyAnti-S-D-Lactoylglutathione Methylglyoxal Lyase antibodyAnti-GLO1 antibody |
Information sourced from Uniprot.org