| Function | Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes. Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function. May promote the survival of mature T lymphocytes upon cytokine withdrawal. May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation. May play a role in mitochondrial DNA segregation in hematopoietic tissues. Is a regulator of liver endothelial cell homeostasis. |
| Protein Name | Gtpase Imap Family Member 5Immune-Associated Nucleotide-Binding Protein 5Immunity-Associated Nucleotide 4-Like 1 ProteinImmunity-Associated Nucleotide 5 ProteinIan-5Hian5Immunity-Associated Protein 3 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type Iv Membrane ProteinEndosomeMultivesicular Body MembraneEndosome MembraneThe Mitochondrial Localization Originally Reported Was Observed With C-Terminally Tagged Protein And Was Not Confirmed In Later Publications |
| Alternative Antibody Names | Anti-Gtpase Imap Family Member 5 antibodyAnti-Immune-Associated Nucleotide-Binding Protein 5 antibodyAnti-Immunity-Associated Nucleotide 4-Like 1 Protein antibodyAnti-Immunity-Associated Nucleotide 5 Protein antibodyAnti-Ian-5 antibodyAnti-Hian5 antibodyAnti-Immunity-Associated Protein 3 antibodyAnti-GIMAP5 antibodyAnti-IAN4L1 antibodyAnti-IAN5 antibodyAnti-IMAP3 antibody |
Information sourced from Uniprot.org
