Anti-GET4 antibody (190-240 aa) (STJ193920)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human GET4 at the amino acid range 190-240
General Information
| Short Description | Rabbit polyclonal anti-Golgi to ER traffic protein 4 homolog (190-240 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GET4 |
| Gene ID | 51608 |
| Uniprot ID | GET4_HUMAN |
| Immunogen | Synthesized peptide derived from the human GET4 at the amino acid range 190-240 |
| Immunogen Region | 190-240 aa |
| Specificity | This antibody detects endogenous levels of GET4 at Human/Mouse |
Additional Info
| Function | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. |
| Protein Name | Golgi To Er Traffic Protein 4 HomologConserved Edge-Expressed ProteinTransmembrane Domain Recognition Complex 35 Kda SubunitTrc35 |
| Database Links | Reactome: R-HSA-9609523 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Golgi To Er Traffic Protein 4 Homolog antibodyAnti-Conserved Edge-Expressed Protein antibodyAnti-Transmembrane Domain Recognition Complex 35 Kda Subunit antibodyAnti-Trc35 antibodyAnti-GET4 antibodyAnti-C7orf20 antibodyAnti-CEE antibodyAnti-TRC35 antibodyAnti-CGI-20 antibody |
Information sourced from Uniprot.org