Anti-GDF11/BMP11 antibody [SAA0430] {PE} (STJA0030854)

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STJA0030854
£282.50 - £423.50
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Host: Mouse
Applications: ELISA/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Growth/Differentiation Factor 11 is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA0430
Conjugation: PE
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: GDF11
Gene ID: 10220
Uniprot ID: GDF11_HUMAN
Post Translational Modifications Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases. This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase.
Function Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3.
Protein Name Growth/Differentiation Factor 11
Gdf-11
Bone Morphogenetic Protein 11
Bmp-11
Cellular Localisation Secreted
Alternative Antibody Names Anti-Growth/Differentiation Factor 11 antibody
Anti-Gdf-11 antibody
Anti-Bone Morphogenetic Protein 11 antibody
Anti-Bmp-11 antibody
Anti-GDF11 antibody
Anti-BMP11 antibody

Information sourced from Uniprot.org