| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
GBP5 |
| Gene ID: |
115362 |
| Uniprot ID: |
GBP5_HUMAN |
| Immunogen Region: |
477-586 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 477-586 of human GBP5 (NP_443174.1). |
| Immunogen Sequence: |
DQALTETEKKKKEAQVKAEA EKAEAQRLAAIQRQNEQMMQ ERERLHQEQVRQMEIAKQNW LAEQQKMQEQQMQEQAAQLS TTFQAQNRSLLSELQHAQRT VNNDDPCVLL |
| Tissue Specificity | Expressed in peripheral blood monocytes (at protein level). |
| Post Translational Modifications | Isoprenylation is required for proper subcellular location. |
| Function | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins. Antigenic tumor-specific truncated splice form. |
| Protein Name | Guanylate-Binding Protein 5Gbp-Ta AntigenGtp-Binding Protein 5Gbp-5Guanine Nucleotide-Binding Protein 5 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneLipid-AnchorGpi-Like-AnchorGolgi Apparatus MembraneCytoplasm |
| Alternative Antibody Names | Anti-Guanylate-Binding Protein 5 antibodyAnti-Gbp-Ta Antigen antibodyAnti-Gtp-Binding Protein 5 antibodyAnti-Gbp-5 antibodyAnti-Guanine Nucleotide-Binding Protein 5 antibodyAnti-GBP5 antibodyAnti-UNQ2427 antibodyAnti-PRO4987 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
