| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GBP1 (383-592) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GBP1 |
| Gene ID: |
2633 |
| Uniprot ID: |
GBP1_HUMAN |
| Immunogen Region: |
383-592 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 383-592 of human GBP1 (NP_002044.2). |
| Immunogen Sequence: |
ELAAQLEKKRDDFCKQNQEA SSDRCSALLQVIFSPLEEEV KAGIYSKPGGYRLFVQKLQD LKKKYYEEPRKGIQAEEILQ TYLKSKESMTDAILQTDQTL TEKEKEIEVERVKAESAQAS AKMLQEMQRKNEQMMEQKER SYQEHLKQLTEKMENDRVQL LKEQERTLALKLQEQEQLLK EGFQKESRIMKNEIQDLQTK MRRRKACTIS |
| Post Translational Modifications | Isoprenylation is required for proper subcellular location. (Microbial infection) Ubiquitinated by S.flexneri IpaH9.8, leading to its degradation by the proteasome, thereby preventing its ability to promote host defense against bacterial infection. |
| Function | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Hydrolyzes GTP to GMP in two consecutive cleavage reactions: GTP is first hydrolyzed to GDP and then to GMP in a processive manner. Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and promotes both autophagy and inflammasome assembly. Promotes host defense against bacterial infections by regulating bacteriolytic peptide generation via its interaction with ubiquitin-binding protein SQSTM1, which delivers monoubiquitinated proteins to autolysosomes for the generation of bacteriolytic peptides. Also acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. Confers protection to several pathogens, including the bacterial pathogens L.monocytogenes and M.bovis BCG as well as the protozoan pathogen T.gondii. Exhibits antiviral activity against influenza virus. |
| Protein Name | Guanylate-Binding Protein 1Gtp-Binding Protein 1Gbp-1Hugbp-1Hgbp1Guanine Nucleotide-Binding Protein 1Interferon-Induced Guanylate-Binding Protein 1 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneLipid-AnchorCytoplasmic SideGolgi Apparatus MembraneCell MembraneCytoplasmSecretedLocalizes To Pathogen-Containing Vacuoles Or To The Cell Surface Of Bacteria That Escaped VacuolesSecreted From Endothelial Cells In The Cerebrospinal FluidUpon Bacterial Challenge And Independently Of Ifng InductionGolgi Membrane Localization Requires Isoprenylation And The Presence Of Another Ifng-Induced Factor |
| Alternative Antibody Names | Anti-Guanylate-Binding Protein 1 antibodyAnti-Gtp-Binding Protein 1 antibodyAnti-Gbp-1 antibodyAnti-Hugbp-1 antibodyAnti-Hgbp1 antibodyAnti-Guanine Nucleotide-Binding Protein 1 antibodyAnti-Interferon-Induced Guanylate-Binding Protein 1 antibodyAnti-GBP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
