| Host: |
Mouse |
| Applications: |
FC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Mouse monoclonal antibody anti-Trans-Acting T-Cell-Specific Transcription Factor Gata-3 is suitable for use in Flow Cytometry research applications. |
| Clonality : |
Monoclonal |
| Clone ID : |
SAA0103 |
| Conjugation: |
APC |
| Isotype: |
IgG1k |
| Formulation: |
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. |
| Purification: |
Purified |
| Concentration: |
0.5 mg/mL |
| Storage Instruction: |
Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Function | Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression. Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. |
| Protein Name | Trans-Acting T-Cell-Specific Transcription Factor Gata-3Gata-Binding Factor 3 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-6785807Reactome: R-HSA-8939236Reactome: R-HSA-9018519Reactome: R-HSA-9830364Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Trans-Acting T-Cell-Specific Transcription Factor Gata-3 antibodyAnti-Gata-Binding Factor 3 antibodyAnti-GATA3 antibody |
Information sourced from Uniprot.org
